Gasotransmitters in health and disease: a mitochondria-centered view

•Gasotransmitters play an important role in maintaining cellular homeostasis.•Disturbed balances in gasotransmitter bioavailability are linked to disease.•The role of gasotransmitters in regulation of mitochondrial function is emerging.•Cytoprotective effects of H2S are gaining more attention.•Slow releasing gasotransmitter donors for therapeutic purposes are being developed.