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Basal Insulin Secretion Capacity Predicts the Initial Response and Maximum Levels of Beta‐hydroxybutyrate During Therapy with the Sodium‐glucose Co‐transporter‐2 Inhibitor Tofogliflozin, in Relation to Weight Loss

Yuichi Sato,Kiyohide Nunoi,Kohei Kaku,Akihiro Yoshida,Hideki Suganami

Diabetes, obesity & metabolism/Diabetes, obesity and metabolism（2019）

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Abstract
To investigate predictors of the initial response of beta‐hydroxybutyrate (BHB) and maximum BHB (max‐BHB) values during long‐term therapy with the sodium‐glucose co‐transporter‐2 inhibitor tofogliflozin (TOFO), and to explore the association of the initial elevation of BHB with subsequent clinical effects in people with type 2 diabetes mellitus.
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Key words
beta-hydroxybutyrate,free fatty acid,insulin secretion,sodium-glucose co-transporter-2 inhibitor,tofogliflozin
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