Exploring The Supra Linear Relationship Between Petco2 And Fmri Signal Change With Ica

The relationships between brain functions and the respiratory system are complex. Disentangling brain activity related to CO2 changes from nonspecific vasoreactivity is a challenge when studying brain activity involved in the control of breathing with fMRI. In this work, we analyzed a dose dependent relationship between arterial CO2 levels and brain response. To accomplish this goal, we developed a gas administration protocol, together with multi-subject ICA and specific nonlinear post-processing analysis. Our results highlighted a supra-linear response to CO2 challenges in brainstem, thalamus and putamen. Results were discussed in the light of current knowledge about the central respiratory network.