Decompensation Prediction in Hemodialysis by a Feedback Model as Identified by Miniature Wearable Sensors

A simple feedback model for blood pressure regulation is described that incorporates multiple autoregulatory feedback mechanisms, all of which may be monitored by a proposed wearable sensor. The feedback signals measured, either directly or indirectly, are heartrate, peripheral vascular resistance, and compression volume. When examined for trends among hemodialysis patients, sustained reduction in feedback amplitudes below those predicted by the model appears to be strongly associated with later blood pressure decompensation.