PIFA/TEMPO‐Mediated Oxidative Cascade Cyclization of Α‐[(β‐amino)propenoyl]‐alkylamides: Access to Polysubstituted 3,7‐Dihydrooxazolo[4,5‐c]pyridine‐2,4,6(5h)‐triones

A novel oxidative cascade cyclization of alpha-[(beta-amino)propenoyl]-alkylamides mediated by phenyl iodine (III) bis(trifluoroacetate) (PIFA) and 2,2,6,6-tetramethyl piperidin-1-oxyl (TEMPO) has been described. This unprecedented transformation features mild reaction conditions, simple execution, high chemo- and regio-selectivity, and thereby provides a facile and efficient protocol for the synthesis of polysubstituted 3,7-dihydro- oxazolo[4,5-c]pyridine-2,4,6-(5 H)-triones.