The fucoidan from sea cucumber Apostichopus japonicus attenuates lipopolysaccharide-challenged liver injury in C57BL/6J mice

•Fucoidan was prepared from A. japonicus and evaluated in LPS-challenged mice.•This fucoidan reduced expression of pro-inflammatory factor: TNF-α, IL-1β and IL-6.•This fucoidan reduced the expression of iNOS, and inactivated MAPK/NF-κb pathway.•This fucoidan suppressed the AKT/mTOR pathway by inhibition of phosphorylation.