Fornix-Region Deep Brain Stimulation–Induced Memory Flashbacks in Alzheimer’s Disease

Wissam Deeb,Bryan Salvato,Leonardo Almeida,Kelly D. Foote,Robert Amaral,Jurgen Germann,Paul B. Rosenberg, David F. Tang-Wai,David A. Wolk,Anna D. Burke,Stephen Salloway,Marwan N. Sabbagh,M. Mallar Chakravarty,Gwenn S. Smith,Constantine G. Lyketsos,Andres M. Lozano,Michael S. Okun

NEW ENGLAND JOURNAL OF MEDICINE（2019）

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摘要

In a trial of stimulation of the fornix and subcallosal regions of the hippocampus involving 42 patients with Alzheimer's disease, 20 patients reported vivid memory flashbacks. The robustness and complexity of the memories increased with increasing voltage applied to the stimulating electrodes.

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