New Liquid Biopsy Markers for the Detection of Central Nervous System Involvement in Childhood Acute Leukemia

Bálint Egyed,Judit C. Sági,Nóra Kutszegi,András Gézsi,Andrea Rzepiel,Csaba Szalai,Gábor T. Kovács,Dániel J. Erdélyi,Ágnes F. Semsei

Clinical Lymphoma Myeloma and Leukemia（2019）

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摘要

Central nervous system (CNS) relapse is a major cause of therapy failure in childhood acute leukemia. Currently there is no more sensitive method for the detection of blast infiltration of meninx than the cerebrospinal fluid (CSF) cytology after lumbar puncture.

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关键词

leukemia,central nervous system involvement,biomarker,ALL,acute lymphoblastic leukemia

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