Application of the LEXSY Leishmania tarentolae system as a recombinant protein expression platform: A review

Tatiana Aparecida de Oliveira,Walmir da Silva,Nancy da Rocha Torres,João Victor Badaró de Moraes,Renato Lima Senra,Tiago Antônio de Oliveira Mendes,Abelardo Silva Júnior,Gustavo Costa Bressan,Juliana Lopes Rangel Fietto

Process Biochemistry（2019）

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摘要

•The production of recombinant glycoproteins is a rapidly expanding field.•LEXSY is a unicellular eukaryotic system to produce recombinant glycoproteins.•Homogeneous mammalian N-glycosylation patterns are produced without sialylation.•History, parameters, advantages, challenges, and practical issues are presented.

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关键词

LEXSY SYSTEM,Recombinant proteins,Leishmania tarentolae,Glycoproteins

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