Selective Deprotection of the Diphenylmethylsilyl (DPMS) Hydroxyl Protecting Group Under Environmentally Responsible, Aqueous Conditions

Nnamdi Akporji,Josh Lieberman,Michael Maser,Masahiko Yoshimura,Zarko Boskovic,Bruce Howard Lipshutz

CHEMCATCHEM（2019）

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摘要

Two new methods for selective deprotection of diphenylmethylsilyl (DPMS) ethers are described. Unmasking can be achieved with either catalytic amounts of perfluoro-1-butanesulfonyl fluoride (a SuFEx reagent) under mild, aqueous micellar conditions, or using stoichiometric amounts of 18-crown-6 ether in aqueous ethanol.

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关键词

green chemistry,selective silyl ether deprotection,SuFEx-catalyzed desilylations,aqueous micellar medium

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