Compartment-restricted and rate-controlled dual drug delivery system using a biosilica-enveloped ferritin cage

•Dual drug delivery system (dDDS) was newly developed by use of biosilica-coated R5-modified ferritin cage.•Doxorubicin (Dox) and paclitaxel (PTX) were loaded separately in different spaces of dDDS system.•Each drug in the inner ferritin or outer silica matrix showed different temporal releases pattern.•Compartment-restricted and rate-controlled dDDS may enhance the efficacy of therapies targeting cells.