Chronic Recurrent Multifocal Osteomyelitis

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare non-infectious inflammatory bone disease of unknown etiology. It presents with recurrent episodes of bone pain and fever, resembling bacterial osteomyelitis, but cultures of lesions are sterile and it is unresponsive to antibiotic therapy. We report a case of 11-year-old girl diagnosed with CRMO, who presented with chronic pain and swelling of bilateral legs. We want to emphasize that CRMO should be kept in mind in the differential diagnosis of recurrent, multifocal bone pain and clinical osteomyelitis.