Calcium Activated Chloride Channels and Their Role in the Myometrium

Calcium activated chloride channels (CaCCs) perform a range of roles in intracellular signalling pathways. In this review, the potential role of these channels in the myometrium is discussed. Of particular interest is the CaCC forming protein ANO1, which has recently been the subject of detailed investigation within the myometrium. It has been robustly demonstrated to promote uterine contractility, and is believed to play an important role in the progression of normal labor. However, the precise mechanism by which this occurs is not yet known. We summarise the evidence to date in support of its role in the myometrium, and consider reports of its function in other settings to gain insight into its potential intracellular role in the uterine myocyte. Finally, in light of the evidence, the future therapeutic implications of this novel tocolytic target are considered.