Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment.
Journal of Advanced Research(2020)
摘要
•The PpBMT crystal structure identified key amino acids in bergaptol conversion.•Protein engineering was used to obtain PpBMT mutants with improved activity.•A high-activity mutant was used to produce bergapten for pharmacological analysis.
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关键词
Coumarin,Bergaptol O-methyltransferase,Rational design,Depigmentation disorder
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