Salubrinal attenuates nitric oxide mediated PERK:IRE1α: ATF-6 signaling and DNA damage in neuronal cells

Sonam Gupta
Sonam Gupta
Parul Gupta
Parul Gupta
Shubhangini Tiwari
Shubhangini Tiwari

Neurochemistry international, pp. 1045812019.

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Keywords:
DNA damageEndoplasmic reticulum stressNitric oxideSalubrinal

Abstract:

The present study was conducted to investigate the effect of salubrinal on nitric oxide mediated endoplasmic reticulum stress signaling and neuronal apoptosis. Rotenone treatment to neuro2a cells caused significantly decreased cell viability, increased cytotoxicity, augmented nitrite levels, increased nitrotyrosine level and augmented lev...More

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