Tim4 regulates NALP3 inflammasome expression and activity during monocyte/macrophage dysfunction in septic shock patients.

Zheng Liu,Kezhe Tan, Lan Bu,Lulong Bo,Wen Ni,Miaomiao Fei,Fang Chen,Xiaoming Deng,Jinbao Li

Burns（2020）

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摘要

•Tim4 expression of monocytes abates in septic shock patients with immunosuppression.•NALP3 inflammasome of monocytes significantly reduces in parallel to Tim4 reduction within the septic patients.•Tim4 enhances inflammatory and phagocytic role of macrophages by activating NALP3 inflammasome.

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关键词

Sepsis,Burn patients,NALP3 inflammasome,Tim4

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