Killer Immunoglobulin-like Receptor-Ligand Interactions Predict Clinical Outcomes Following Unrelated Donor Transplants.

•An adaptive mathematical model has been developed to quantify killer immunoglobulin-like receptor (KIR)-KIR ligand (KIRL) interactions.•The magnitude of inhibitory and missing KIR-KIRL interactions predicts overall survival and relapse risk following HLA-matched unrelated donor (URD) hematopoietic cell transplantation (HCT).•Cumulative known KIR-KIRL interactions predict clinical outcomes after URD HCT.•High inhibitory KIR-KIRL interaction scores correlates with robust natural killer cell recovery after URD HCT.