Xylosyltransferase-deficient human HEK293 cells show a strongly reduced proliferation capacity and viability.

Bastian Fischer,Thanh-Diep Ly,Vanessa Schmidt,Doris Hendig,Joachim Kuhn,Cornelius Knabbe,Isabel Faust

Biochemical and Biophysical Research Communications（2020）

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摘要

Human xylosyltransferases-I and –II (XT-I and XT-II) catalyze the initial and rate-limiting step in proteoglycan (PG)-biosynthesis. Because PG are major components of the extracellular matrix (ECM), an alternated XT expression is associated with the manifestation of ECM-related diseases.

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关键词

CRISPR/Cas9,Extracellular matrix,HEK293 cells,Xylosyltransferase

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Xylosyltransferase-deficient human HEK293 cells show a strongly reduced proliferation capacity and viability.

Xylosyltransferase-deficient human HEK293 cells show a strongly reduced proliferation capacity and viability.