Cu-Catalyzed Direct Diversification of 2‑(2-Bromophenyl)­quinazolin-4(3H)‑ones through Orthogonal Reactivity Modulation

Organic Letters(2019)

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摘要
A modular strategy to obtain three different products from a single substrate was developed. The present methodology unveils new step-economical and cost-efficient routes to access diverse fused quinazolino­quinazolinone derivatives which are not prevalent in literature. Owing to the importance of quinazolinones in therapeutics, quick access to the arena of these scaffolds could be a valuable addition to the scientific domain of heterocyclic chemistry.
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cu-catalyzed
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