A multifunctional nanoplatform based on MoS 2 -nanosheets for targeted drug delivery and chemo-photothermal therapy.

•A multifunctional platform based on melanin (Mel)-decorated, hyaluronic acid (HA)-modified MoS2 sheets has been designed.•The nanoplatform has high DOX loading capability and exhibits pH and near-infrared laser response to DOX release.•The synergetic effect in the enhancement of photothermal efficiency was achieved.•The engineered HPMP@(DOX/Mel) nanoplatform exhibits excellent synergistic chemo-photothermal effect for cancer therapy.