African ST173 Cryptococcus deuterogattii strains are commonly less susceptible to fluconazole: an unclear mechanism of resistance.

S Bertout,F Roger,P Drakulovski,A S Martin,T Gouveia,F Kassi,H Menan,D Krasteva,E Delaporte,V Bellet

Journal of Global Antimicrobial Resistance（2020）

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摘要

•All Ivorian Cryptococcus deuterogattii isolates were identified as ST173 by MLST.•64.3% (18/28) of isolates had a fluconazole (FCZ) MIC of ≥16μg/mL.•FCZ exposure increased AFR1 mRNA expression, especially in isolates with high FCZ MICs.•Resistance mechanisms described in Cryptococcus neoformans were not involved in C. deuterogattii ST173 isolates.

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关键词

Cryptococcus gattii species complex,Cryptococcus deuterogattii,VGII genotype,Fluconazole,Resistance mechanism

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