The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial.

Daniel K Burns,Carl Chiang,Kathleen A Welsh-Bohmer,Stephen K Brannan,Meredith Culp,Janet O'Neil,Grant Runyan,Patrick Harrigan,Brenda L Plassman,Michael Lutz,Eric Lai,Stephen Haneline,David Yarnall, Deborah Yarbrough,Craig Metz, Sridevi Ponduru,Scott Sundseth,Ann M Saunders

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2019）

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摘要

•Applied a genetics-based algorithm to enrich for near-term risk of mild cognitive impairment due to Alzheimer's disease.•Assessed early cognitive decline with a multidomain neuropsychological test battery.•Utilized time to mild cognitive impairment due to Alzheimer's disease as study endpoint.•Simultaneous evaluation of a biomarker and therapeutic.

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关键词

Clinical trial design,Delay of onset,Genetic risk for AD,Mild cognitive impairment due to AD,Time to event,Trial population enrichment

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