New Delhi Metallo-beta-Lactamase 1-Producing Klebsiella pneumoniae ST719 Isolated from a Neonate in China

The spread of carbapenem-resistant Klebsiella pneumoniae has become a significant problem for public health in recent years. In this study, we reported a New Delhi metallo-beta-lactamase 1 (NDM-1)-producing K. pneumoniae strain KP14003 from a neonate in Beijing, China. Whole-genome sequencing was performed. The strain belonged to sequence type ST719. Coexistence of bla(NDM-1) and bla(SHV-12) was found on a self-transferable plasmid, which had a typical IncX3 backbone. The horizontal transfer of bla(NDM-1) was associated with Tn125 followed by possible transposition events. Other class A extended-spectrum beta-lactamase genes (bla(SHV-27) and bla(TEM-1)) were also identified on chromosome or plasmid. The dissemination of NDM-1-producing K. pneumoniae causes great challenges to the treatment of clinical infections. Effective actions need to be taken to control the further spread of this pathogen.