Human CD8+ Tregs Expressing a MHC-specific CAR Display Enhanced Suppression of Human Skin Rejection and GVHD in NSG Mice

Severine Bezie,Beatrice Charreau,Nadege Vimond,Juliette Lasselin,Nathalie Gerard,Veronique Nerriere-Daguin,Frederique Bellier-Waast,Franck Duteille,Ignacio Anegon,Carole Guillonneau

Blood Advances（2019）

引用 49|浏览25

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摘要

Key Points First description of the relevance of the CAR engineering approach to develop CAR-CD8+ Tregs for clinical trials in transplantation. A2-CAR CD8+ Treg interactions with HLA-A*02+ ECs induce a noncytotoxic fine-tuned and protolerogenic activation of ECs.

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CAR T Cells

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