An autoantibody against a 48-Kd fragment of human DNA-topoiomerase I in breast cancer: Implication for diagnosis and prognosis, and antibody-dependent cellular cytotoxicity in vitro

•Anti-TOPO48 autoantibody can be used as a potential biomarker for early diagnosis of breast cancer.•Anti-TOPO48 autoantibody is a potential biomarker indicating favorable prognosis of BC patients.•Anti-TOPO48 autoantibody can induce significant ADCC activities to destroy BC cells in vitro.•ADCC activities are significantly correlated with NK cells, NKT cells, and CD4+/CD8+ T cells.•Anti-TOPO48 autoantibody represents an early index of immune response to the TAA.•Anti-TOPO48 autoantibody also involves in host immune defense mechanisms to destroy cancer cells.