Miniaturized magnetic bead-actuators for force-clamp spectroscopy-based single-molecule measurements.

Ultramicroscopy（2020）

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摘要

•We introduce a new force-clamp method for AFM using miniaturized magnetic beads as manipulators.•The new method improves the stability of the AFM system.•The new method enables force-clamp experiments without an active feedback.•Automatic digital controller enables high data throughput.

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关键词

Atomic force microscopy,Single-molecule mechanics,Force-clamp spectroscopy,Biotin,Streptavidin

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