Urate hydroperoxide oxidizes endothelial cell surface protein disulfide isomerase-A1 and impairs adherence.

Marcela Franco Mineiro,Eliziane de Souza Patricio,Álbert Souza Peixoto,Thaís Larissa Silva Araujo,Railmara Pereira da Silva,Ana Iochabel Soares Moretti,Filipe Silva Lima,Francisco Rafael Martins Laurindo,Flavia Carla Meotti

Biochimica et Biophysica Acta (BBA) - General Subjects（2020）

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摘要

•Urate hydroperoxide oxidizes PDI at a rate of constant of 6 × 103 M−1 s−1.•Urate hydroperoxide oxidized cell surface PDI in HUVECs•PDI oxidation, alkylation or inhibition decreased HUVECs adherence.

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关键词

Urate hydroperoxide,Cell surface PDI,Thiol oxidation,HUVEC

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