Rebound of multiple sclerosis activity after fingolimod withdrawal due to planning pregnancy: Analysis of predisposing factors.

•3 (42%) patients suffered rebound after fingolimod cessation for pregnancy planning.•Pregnancy failed to halt such exaggerated inflammatory activity.•New-borns were delivered healthy despite using steroids throughout pregnancy.•Lymphocyte count <300/ul was related to reappearance of activity disease.