Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.

Lisandra Muñoz-Hidalgo,Teresa San-Miguel,Javier Megías,Daniel Monleón,Lara Navarro,Pedro Roldán,Miguel Cerdá-Nicolás,Concha López-Ginés

Neoplasia（2020）

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摘要

Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration.

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关键词

ANOVA,BCL2,CDH1,CHD7,CDK6,CDKN1B,CDKN2A,CDKN2B,CNAs,CNS,CNV-load,CREM,DAPI,EGFR,EGFRvIII,FISH,GBM,GFAP,H-amp GB,HIC1,IDH1,IDH2,IHC,LARGE1,MLPA,MYBPC3,L-amp GB,N-amp GB,p53-pat,PAH,PARK2,PTEN,RARB,RB-pat,TKR-pat,TCGA,TMA,wt,WHO

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