Oxyresveratrol drives caspase-independent apoptosis-like cell death in MDA-MB-231 breast cancer cells through the induction of ROS.

Damu Sunilkumar,G Drishya,Aneesh Chandrasekharan,Sanu K Shaji,Chinchu Bose,Jennifer Jossart,J Jefferson P Perry,Nandita Mishra,Geetha B Kumar,Bipin G Nair

Biochemical Pharmacology（2020）

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摘要

Oxyresveratrol drives a caspase-independent cell death with apoptosis-like features, through the induction of ROS, resulting in translocation of AIF into the nucleus, PARP cleavage, DNA fragmentation and cell death.

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关键词

OXY,MTT,AO,CPT,PI,NAC,FCCP,QVD-OPH,ROS,AIF,PARP,FITC,DCFDA,mt-roGFP

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