Clinical Evidence on the Interaction Between MLK4, KRAS and Microsatellite Instability to Determine the Prognosis of Early-Stage Colorectal Carcinoma.

Lydia Brandl,David Horst,Thomas G P Grünewald,Julia Mayerle,Andrea Sendelhofert,Jens Neumann,Thomas Kirchner,Enrico N De Toni

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2019）

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摘要

By providing the first report from clinical specimens on the prognostic significance of MLK4, we define an oncogenic loss-of-function of this kinase and suggest a possible role in the interaction with KRAS signaling in determining an aggressive phenotype of CRC. These findings warrant the further investigation of MLK4 in wider cohorts and various clinical settings.

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关键词

MLK4, KRAS, MSI, MSS, Colorectal carcinomas, Prognosis

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