Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.

•In vitro, 0.1 % to 0.00078125 % pranoprofen cause necroptosis and apoptosis in HCS cells.•0.00625 % pranoprofen induces apoptosis through ROS-mediated caspase-dependent and caspase-independent pathways.•In vivo, 0.1 % pranoprofen causes apoptosis-like ultrastructural alterations in rabbit corneal stromal cells.