Biochemical Comparison Of Vwf/Fviii Concentrates - Are There Differences In Product Characteristics And Purity?

Introduction: Product characteristics and purity are important in assessing the safety and efficacy of VWF/FVIII products. Purity has been defined as the specific activity of the active ingredients in relation to the total protein in the products. This is important because it indicates the content of co-purified plasma proteins in the product. An extensive biochemical comparison of several VWF/FVIII concentrates licensed for the treatment of Haemophilia A and/or von Willebrand disease (VWD), including the novel new generation VWF/FVIII concentrate (Wilate), was performed to compare their properties.