COGNITION AND CEREBRAL SPINAL FLUID BIOMARKERS RELATIONSHIP IN AD

CSF biomarkers reflect the pathophysiology of AD. CSF Aβ decrease is found long before clinical cognitive decline. Aβ accumulation in brain is an aging process and no relationship was found between Aβ deposition and disease progression in AD. However, Tau accumulation is regarded more parallel to clinical manifestation. 48 CSF samples were collected from Dementia &Leukoencephalopathy Clinic in PUMCH. The CSF sampling, storage and test with INNOTEST followed the standard operational manual. All patients were diagnosed AD based on clinical features and neuroimaging. Cognition test battery included MMSE, MoCA, ADL, CDR and other specialized domain examination. They were divided into three groups according to MMSE score, which were severe (MMSE 0-10), moderate (MMSE 11-20) and mild (MMSE 21-30). 7 mild, 15 moderate and 26 severe cases were included. The Aβ42 levels of the three groups were 517.2±97.43pg/ml, 506.6±37.68pg/ml, 472.2±22.93pg/ml, respectively. The T-Tau levels of the three groups were 487.8±168.3pg/ml, 617.5±121.3pg/ml, 814.3±94.16pg/ml, respectively. The P-Tau levels of the three groups were 60.19±13.64pg/ml, 80.30±10.35pg/ml, 97.07±8.63pg/ml, respectively. No difference was found in Aβ42 levels among the three groups. An increasing trend was found in both T-tau and P-Tau levels along with the cognition deteriorate, although not statistically significant.