Recovery of policlonal immunoglobulins as a predictor factor of increased progression-free survival and overall survival in patients with multiple myeloma ineligible for ASCT

Immunoparesis is the suppression of polyclonal immunoglobulins (Igs) and is present in about 85% of patients diagnosed of multiple myeloma (MM). Our group recently demonstrated that the normalization of polyclonal Igs after ASCT is a predictor factor for longer progression-free survival (PFS) and overall survival (OS). However, the impact of this factor in patients who are ASCT-ineligible has not been determined yet.