Severe Lipoatrophy in a Patient With Type 2 Diabetes in Response to Human Insulin Analogs Glargine and Degludec: Possible Involvement of CD4 T Cell-Mediated Tissue Remodeling.

Lipoatrophy in response to insulin therapy is a rare condition resulting in a loss of subcutaneous adipose tissue at the site of injection. Since the introduction of humanized insulins, insulin-induced lipoatrophy (IIL) is almost exclusively associated with T1D. IIL was suggested to be an aspect of autoimmunity (1,2), but its underlying pathophysiology is poorly understood. …