Synthesis and evaluation of 4-(1,3,4-oxadiazol-2-yl)-benzenesulfonamides as potent carbonic anhydrase inhibitors.

Chaofu Yang,Yan Feng,Xu Yang,Mingxia Sun,Zhenwang Li,Xuan Liu,Liang Lu,Xianyu Sun,Jiwen Zhang,Xinhua He

Bioorganic & Medicinal Chemistry Letters（2020）

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摘要

•A series of benzenesulfonamide derivatives have been synthesized.•The titled compounds were screened for hCA I and II in vitro.•The selected compounds were evaluated anti-hypoxia activity in vivo.•In Silico Docking Simulations were in support of SAR.

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关键词

Benzenesulfonamide derivatives,hCA inhibitors,Cytotoxicity,Anti-hypoxia,Docking simulations

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