Association Between Sleep Disturbances, Fear of Hypoglycemia and Psychological Well-Being in Adults with Type 1 Diabetes Mellitus, Data from Cross-Sectional VARDIA Study.

Aim: To assess the relationship between sleep quality, fear of hypoglycemia, glycemic variability and psychological well-being in type 1 diabetes mellitus. Methods: Our data were provided by the VARDIA Study, a multicentric cross-sectional study conducted between June and December 2015. Sleep characteristics were assessed by the Pittsburgh Sleep Quality Index (PSQI). Fear of hypoglycemia and psychological well-being were measured with the Hypoglycemia Fear Survey version II (HFS-II) and the Hospital Anxiety and Depression Scale (HADS), respectively. Glycemic variability (GV) was determined using the CV of three 7-point self-monitoring blood glucose profiles and the mean amplitude of glycemic excursion (MAGE). Results: 315 patients were eligible for PSQI questionnaire analysis: 54% women, mean age 47 +/- 15, mean diabetes duration of 24 +/- 13 years, HbA1c of 7.6 +/- 0.9% (60 +/- 7,5mmol/mol). Average PSQI score was 6.0 +/- 3.3 and 59.8% of the patients had a PSQI score > 5. HFS-II score and HADS were significantly higher among "poor" sleepers (p < 0.0001) and PSQI score was positively associated with HADS (b = 0.22; 95% CI = 0.08;0.35). GV evaluated by CV or MAGE did not differ between "poor" and "good" sleepers (p = 0.28 and 0.54, respectively). Conclusions: Adult patients with type 1 diabetes have sleep disturbances which correlate with psychological well-being. This study suggests that psychological management can be a target to improve sleep quality in adults with type 1 diabetes mellitus. (C) 2019 Elsevier B.V. All rights reserved.