Inhibition of lipolysis: a novel explanation for the hypothermic actions of Acetaminophen in Non-Febrile Rodents.

•In terms of antipyretic and hypothermia, the peripheral actions of acetaminophen and related compounds are more important than inhibition of cyclooxygenases centrally.•The antipyretic and hypothermic effects of acetaminophen may be due to the inhibition of lipolysis.•The inhibition of mitochondrial electron transport chain by acetaminophen may explain both its antipyretic and hypothermic effects.