Bioanalytical methods for therapeutic monoclonal antibodies and antibody–drug conjugates: A review of recent advances and future perspectives

Kenichiro Todoroki,Hajime Mizuno,Eiji Sugiyama,Toshimasa Toyo’oka

Journal of Pharmaceutical and Biomedical Analysis（2020）

引用 30|浏览9

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摘要

•Current bioanalytical methods for therapeutic mAbs and ADCs were summarized.•Three (bottom-up, top-down, and middle-down) proteomics approaches were outlined.•We also introduced recent purification methods for therapeutic mAbs and ADCs.

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关键词

Therapeutic monoclonal antibodies,Bioanalysis,antibody–drug conjugate,Liquid chromatography,Mass spectrometry

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