Anti-Tumor Effect Of The Ezh1/2 Dual Inhibitor Valemetostat Against Diffuse Large B-Cell Lymphoma Via Modulation Of B-Cell Receptor Signaling And C-Myc Signaling Pathways

Yasuhiro Hama,Toshihiro Banjo,Daisuke Honma,Yoshimi Takata,Emi Nosaka,Machiko Shiroishi,Kenji Watanabe,Yuka Yamamoto,Tsuyoshi Hirata, Rika Nakano,Koichiro Inaki,Hiroki Goto,Yusuke Totoki, Miki Kataoka,Kyungtaek Lim,Chisa Wada,Eiji Kumazawa,Shinji Tsutsumi

BLOOD（2019）

引用 4|浏览3

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摘要

Enhancer of zeste homolog (EZH) 1 and its close homolog EZH2 are component of polycomb repressive complex 2 (PRC2), and play a partially redundant and crucial role for the maintenance of transcriptional repression by tri-methylating histone H3 lysine 27 (H3K27). Hyper tri-methylation of H3K27 have been associated with lymphoma and myeloma progression, suggesting PRC2 is a therapeutic target for hematological malignancies.

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