Tumor Circulating Plasma Cells Detected By Flow Cytometric Single Platform Method Correlate With Clinical Response To Therapy And Unfavorable Patients' Characteristics

Vittorio Emanuele Muccio,Milena Gilestro,Elona Saraci,Andrea Capra, Alessandro Costa,Marina Ruggeri,Simona Caltagirone,Daniela Oddolo, Chiara Mussatto,Pellegrino Musto,Lucia Pantani,Vincenzo Pavone,Sonia Ronconi,Iolanda Donatella Vincelli,Anna Maria Cafro,Claudia Cellini,Vanessa Innao,Eugenio Piro,Mario Boccadoro,Paola Omedé

BLOOD（2019）

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摘要

Background: In multiple myeloma (MM), different clinical parameters and molecular prognostic factors can predict disease course and response to therapy. The classification of myeloma patients includes laboratory parameters associated with higher tumor activity, resistance to therapy and proliferative competence. Tumor circulating plasma cells (TCPC) in MM patients showed a strong correlation with a more aggressive disease.

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tumor,cells

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