Label-Free Microscopic Imaging Based on the Random Matrix Theory in Wavefront Shaping

Wavefront shaping technology has mainly been applied to microscopic fluorescence imaging through turbid media, with the advantages of high resolution and imaging depth beyond the ballistic regime. However, fluorescence needs to be introduced extrinsically and the field of view is limited by memory effects. Here we propose a new method for microscopic imaging light transmission through turbid media, which has the advantages of label-free and discretional field of view size, based on transmission-matrix-based wavefront shaping and the random matrix theory. We also verify that a target of absorber behind the strong scattering media can be imaged with high resolution in the experiment. Our method opens a new avenue for the research and application of wavefront shaping.