Impaired delivery of cholesterol effluxed from macrophages to hepatocytes by serum from CKD patients may underlie increased CVD risk

Graham T. Gipson,Salvatore Carbone,Jing Wang,Dave L. Dixon,Ion S. Jovin,Daniel E. Carl,Todd W. Gehr,Shobha Ghosh

Kidney International Reports（2020）

引用 10|浏览18

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摘要

These results suggest that aberrations in delivery of cholesterol effluxed from macrophage foam cells to liver for final elimination or the last step of reverse cholesterol transport, may underlie the increased risk of CAD in patients with CKD.

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关键词

cardiovascular disease risk,chronic kidney disease,delivery of cholesterol to the liver,reverse cholesterol transport,serum cholesterol efflux capacity

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