Fludarabine, High Dose Cytarabine And Idarubicin-Based Induction Is Highly Effective In Young Aml Patients With Concomitant Npm1 And Flt3-Itd Mutation Irrespectively Of Flt3-Itd Allelic Burden

Background: The presence of FLT3 “internal tandem duplication” (FLT3-ITD) mutation is associated with poor prognosis in acute myeloid leukemia (AML). However, the concomitant presence of NPM1 mutation (NPM1-mut) partially overcomes the negative prognostic impact of FLT3-ITD, which is also modulated by FLT3-ITD/wild-type allelic ratio. NPM1 and FLT3 mutational status assessment is strongly recommended for risk stratificationat diagnosis by the last European Leukemia Net (ELN) guidelines.