Anti-Candida albicans biofilm activity of extracts from two selected indigenous Algerian plants: Clematis flammula and Fraxinus angustifolia

Candida albicans biofilm is associated with high rates of morbidity and resistance to antifungals. The aim of the present study was to evaluate the anti-Candida albicans biofilm activity of some indigenous Algerian medicinal plant extracts: Clematis flammula and Fraxinus angustifolia and their influence on the virulence factors of C. albicans. The anti-biofilm activity was determined using crystal violet assay while the cell surface hydrophobicity (CSH) was estimated in a water-hydrocarbon two-phase assay. Moreover, germ tube formation and hyphae elongation were assessed microscopically.