Pharmacogenetic Variants in MTHFR Gene are Significant Predictors of Methotrexate Toxicities in Bangladeshi Patients With Acute Lymphoblastic Leukemia.

Fatema Tuz Zahra,Noor Ahmed Nahid,Md Reazul Islam,Mir Md Abdullah Al-Mamun,Mohd Nazmul Hasan Apu,Zabun Nahar,Amin Lutful Kabir,Subrata K Biswas,Maizbha Uddin Ahmed,Mohammad Safiqul Islam,Abul Hasnat

Clinical Lymphoma Myeloma and Leukemia（2020）

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摘要

The risk of elevated plasma homocysteine level was 5 to 6 times higher for both polymorphisms. This study may help to identify the patients who are at higher risk for MTX-related toxicities.

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关键词

Acute lymphoblastic leukemia,Homocysteine,Methotrexate,MTHFR,Toxicities

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