Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials.

T Yoshino,J M Cleary,E Van Cutsem,R J Mayer,A Ohtsu,E Shinozaki,A Falcone,K Yamazaki,T Nishina,R Garcia-Carbonero,Y Komatsu,H Baba,G Argilés,A Tsuji,A Sobrero,K Yamaguchi,M Peeters, K Muro,A Zaniboni,N Sugimoto,Y Shimada,Y Tsuji,H S Hochster,T Moriwaki,B Tran,T Esaki,C Hamada,T Tanase, F Benedetti,L Makris, F Yamashita,H-J Lenz

Annals of Oncology（2020）

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摘要

•Patients with higher FTD exposure had a significantly increased risk of CIN.•In RECOURSE, FTD/TPI-treated patients who developed CIN had improved OS and PFS compared with placebo and those with no CIN.•Similar results from J003 validated the RECOURSE results.

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关键词

chemotherapy-induced neutropenia,FTD/TPI,J003,metastatic colorectal cancer,RECOURSE

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