Correlation Between Immunoglobulin Dose Administered And Plasma Neutralization Of Streptococcal Superantigens In Patients With Necrotizing Soft Tissue Infections

Helena Bergsten,Martin Bruun Madsen,Francois Bergey,Ole Hyldegaard,Steinar Skrede,Per Arnell,Oddvar Oppegaard,Andreas Itzek,Anders Perner,Mattias Svensson,Anna Norrby-Teglund

CLINICAL INFECTIOUS DISEASES（2020）

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摘要

Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-.67, P<.0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens.

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intravenous immunoglobulin G, necrotizing soft tissue infections, necrotizing fasciitis, superantigens, Streptococcus pyogenes

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