Development of novel carbazole derivatives with effective multifunctional action against Alzheimer's diseases: Design, synthesis, in silico, in vitro and in vivo investigation.

•A series of novel carbazole derivatives has been developed as potent multifunctional agents against Alzheimer’s disease.•These compounds appeared to be potent AChE inhibitors, Aβ aggregation inhibitors, anti-oxidant and neuroprotective agents.•MT-1 and MT-6 were most potent multifunctional agents in the entire series.•MT-6 have shown effective neuroprotective action against H2O2 induce toxicity in SHSY-5Y cells.•MT-6 was evaluated against scopolamine induced dementia model of mice and this compound actively improved memory deficit and cognition impairment in this model.